McAfee AntiVirus Plus makes you click around more than you should to perform simple tasks. McAfee AntiVirus Plus (for Mac): Interface Still, that's less than half of Sophos' full-scan completion time of 2:56, but much longer than Malwarebytes' blink-and-you-miss-it full-scan time of 16 seconds.
On average, McAfee's full scans took 1 hour and 17 minutes, so you'd spend a while waiting to notice said slowdown. (McAfee AntiVirus Plus doesn't offer a quick scan for Macs.) Most of the programs got a two-digit performance slowdown - from Norton at 13% to Kaspersky at 41% - and only Sophos (7%) had a one-digit bump. That's the biggest performance slowdown during a full scan that we saw. During a McAfee full-system scan, the VLOOKUP test finished in 5 minutes and 15 seconds, signifying a performance dip of 47%.